PATHOLOGY AND LABORATORY MEDICINE DEPARTMENT
The Pathology and Laboratory Medicine Department is at the forefront of laboratory diagnostics for the hospital. It is composed of 4 Divisions, 7 Clinical Pathology Sections, 2 National Reference Laboratories and a Subnational Laboratory – all using state-of-the-art equipment, adhering to international standards, and manned by highly competent laboratory scientists.
- Clinical Pathology
- Anatomic Pathology
- Surgical Pathology
- Special Stains
- National Reference Laboratories
- Molecular Diagnostics and Cellular Therapeutics Laboratory
- Molecular Diagnostics for Cellular Therapeutics
- Cellular Therapeutics (Clinical Program)
The LCP Blood Bank is designated by the National Voluntary Blood Services Program (NVBSP) as “BB+” or Blood Bank with Additional Functions, one of the highest classifications for blood service facilities.
The Blood Bank is responsible for ensuring that each blood unit released to the patient is the most compatible and safest blood. As a blood storage facility, the Blood Bank aims to be able to have readily available blood for transfusion through its voluntary blood donation program. Aside from regular whole blood donation, the section also offers apheresis service, wherein only the desired cellular component is taken from the donor. During this pandemic, the section also collects and offers convalescent plasma an alternative treatment for those with COVID-19.
- ABO Typing
- Antibody Screening
- Indirect Coomb’s test
- Direct Coomb’s test
- Immediate spin
- Rh typing
- TTI Screening
- Blood products
- Whole Blood
- Packed RBC
- Platelet Concentrate
- Fresh Frozen Plasma
- COVID-19 Convalescent Plasma
Blood Donor Services
The Blood Donor Services is the blood collecting arm of the Blood Bank. It is responsible in promulgating the voluntary blood donation program of the Department of Health.
The Blood Donor Services is in charge of doing mass blood donation (MBD) activities outside the hospital and within the institution. Prospective blood donors are screened by Blood Bank Medical Officers whether they are fit to donate blood. The service is also responsible for the separation of whole blood to its component units: packed RBC, platelets, and plasma; and for screening of blood units for blood transmissible diseases.
The service is located within the Pathology and Laboratory Medicine Department, Ground Floor, Lung Center of the Philippines Main Building, and accepts voluntary blood donors daily (including weekends and holidays) from 9am to 6pm. But due to the COVID-19 pandemic, donors are requested to call beforehand to be scheduled in order to follow physical distancing and maximum room capacity regulations.
For organizations planning on holding mass blood donations and would like to partner with us, you may coordinate with the Blood Donor Services at local 1184 or 1185, Monday to Friday (except holidays) from 9am to 5pm.
The Clinical Chemistry Section offers a wide array of biochemical analysis for blood, urine, and other body fluids using reputable equipment following the industry’s international gold standards.
Each result is assured of quality through the section’s participation in national and international external quality assurance programs (EQAS).
Unique to its being the biochemistry laboratory of the Lung Center of the Philippines, it is one of the few laboratories that do chemical analysis on pleural fluid.
The Clinical Chemistry Section also offers bundled tests for specific conditions like Liver Profile, Lipid Profile, etc.
List of Tests:
- Fasting Blood Sugar (FBS)
- Random Blood Sugar (RBS)
- 2 hour Post Prandial Blood Sugar (2′ PBSS)
- Oral Glucose Challenge Test (OGCT)
- Oral Glucose Tolerance Test (OGTT)
- Hemoglobin A1c (HgbA1c)
- Blood Urea Nitrogen (BUN)
- Uric Acid (BUA)
- Asparate Aminotransferase (SGOT/AST)
- Alanine Aminotransferase (SGPT/ALT)
- Lactate Dehydrogenase (LDH)
- Calcium (Ca)
- Magnesium (Mg)
- Alkaline Phosphatase (ALP)
- Lipid Profile
- Total Protein
- Total Protein
- A/G ratio
- Total Bilirubin (TBIL)
- Direct Bilirubin (DBIL)
- Indirect Bilirubin (IBIL)
- Creatinine Kinase- MB (CKMB)
- Creatinine Kinase- MM (CKMM)
- Troponin I- Quantitative
- Sodium (Na)
- Potassium (K)
- Chloride (Cl)
- Serum Osmolality
Pleural/Peritoneal/Pericardial/Ascitic Fluid Chemistry:
- Total Protein
The Hematology Section is responsible for the analysis of blood with regards to its quantity, morphology, and function.
The section closely works together with the Hematology-Oncology and Thoracic-Oncology sections of the hospital to provide diagnosis of their patients.
The LCP Hematology Section is also one of the few hospitals that perform Special Coagulation Studies.
Aside from blood, the section also accepts cell quantity and morphology analysis of selected body fluids.
- Complete Blood Count
- White Blood Cell Count
- WBC Differential Count
- Red Blood Cell Count
- RBC Indices
- Mean Corpuscular Volume (MCV)
- Mean Corpuscular Hemoglobin (MCH)
- Mean Corpuscular Hemoglobin Concentration (MCHC)
- RBC Distribution Width (RDW)
- Platelet Count
- Mean Platelet Volume (MPV)
- Reticulocyte Count
- Erythrocyte Sedimentation Rate
- Malaria Smear Evaluation
- Peripheral Blood Smear Evaluation
- Bone Marrow Aspiration Evaluation
- Mesothelial Count
- Cerebrospinal Fluid (CSF) Analysis
- Body Fluid Cell Count
- Prothrombin Time (PT)
- Activated Partial Thromboplastin Time (APTT)
- Clotting Time
- Bleeding Time (Ivy Method)
- Clot Retraction Time
- Hematocrit for pleural fluid
- LE Cell Test
- Fibrin Degradation Product
- Mixing Studies PT
- Mixing Studies APTT
- Special Coagulation Tests
- Quantitative D-Dimer
- Fibrinogen Level
- Factor VIII
- Factor IX
- Factor XIII
- Anti-thrombin III
- Protein C
- Thrombin Time
Considered as one of the most basic components of the clinical laboratory, the section delves with the analysis and evaluation of urine, stool, and body fluids through light microscopy and through visual chemical reactions.
- Urine Microscopy
- Urine Specific Gravity
- Urine Chemical Tests
- Fecal Occult Blood Test
- Semen/Sperm Analysis
- Body Fluid Analysis
- Peritoneal Fluid
- Pleural Fluid
- Cerebrospinal Fluid
- Synovial Fluid
- Pregnancy Test
The Immunology Section deals with examinations that detects antigens and antibodies produced by diseases. Using the industry standard equipment in antibody and antigen detection, the section can identify the presence of infectious, autoimmune, and neoplastic diseases. And with the COVID-19 pandemic, it has added inflammatory biomarkers in its list of tests offered.
Common immunologic tests performed are for:
- Anti-HIV Screening Test
- CD4 Count
- Hepatitis B
- Anti-HBc Total
- Hepatitis C
- Hepatitis A
- Anti-HAV IgM
- Particle Agglutination test for Syphilis (TPPA)
- Dengue NS1
- Dengue IgM/IgG
- Serum Tumor Markers
- Mycobacterium Tuberculosis
- Interferon Gamma (Quantiferon TB Gold Test)
- Thyroid Function
- SARS-CoV-2 IgG/IgM (CLIA)
- COVID-19 Rapid Antibody IgG/IgM (ICT)
- Inflammatory Biomarkers
- C-Reactive Protein
The Section of Microbiology of the Department of Pathology and Laboratory offers examinations for the diagnosis of infections caused by bacteria, fungi, mycobacteria, as well as emerging and re-emerging diseases.
Most of the specimens received in the section are from respiratory sources (sputum, ETA, pleural fluid, bronchial aspirates) in addition to blood, body fluids and tissues.
The section performs culture, identification and drug sensitivity testing using manual methods and automated methods by using the Vitek System. The Vitek System provides automated identification of the organism as well as sensitivity to antibiotics.
With the purchase of BioFire FilmArray TORCH system equipment, the section can now perform molecular tests to identify common pathogens within hours using multiplex PCR technology.
Services offered are:
- Gram Stain
- Bacteriological Culture and Sensitivity
- Culture & Sensitivity
- Stock Isolate/antibiotic testing
- Bacteriological Culture and Identification for Environmental Surveillance
- Fungal Culture
- AFB Stain
- AFB Culture and Sensitivity
- India Ink Test
- KOH Smear
- Infectious Molecular Stat Laboratory
- SARS-CoV-2 Xpert Xpress (GeneXpert)
- BioFire FilmArray Respiratory Panel
- BioFire FilmArray Pneumonia Panel
- BioFire FilmArray Blood Culture ID Panel
Diagnostic procedures for tuberculosis are done in the TB Laboratory. Direct sputum smear microscopy, TB culture and sensitivity testing are just some of the tests done.
Recent trends in the diagnosis of diseases have shifted attention to molecular diagnostics and the diagnosis of TB is no exception. TB PCR (Polymerase Chain Reaction) genotyping, Genexpert MTB–Rif Assay, and TB-LAMP are available in the laboratory.
- Direct sputum smear microscopy (DSSM)
- TB Culture and Sensitivity
- TB PCR
- TB GeneXpert (MTB-Rif Assay)
Pursuant to Department Personnel Order No. 2009-2441, the Lung Center of the Philippines (LCP) Department of Pathology and Laboratory in 2009 was tapped to assist the Research Institute for Tropical Medicine (RITM) in the detection of Pandemic Influenza AH1N1 using Real Time PCR.
In 2014, Lung Center of the Philippines was again designated as the Referral Center for Emerging and Re-Emerging Respiratory Tract Diseases such as the Middle East Respiratory Syndrome – Coronavirus (MERsCoV) by Department Memorandum No. 2014-0365. In order to carry out this function, the Department of Pathology and Laboratory established the Special Pathogen Laboratory.
The Special Pathogen Laboratory, as a DOH sentinel site, also plays a part in the surveillance of Severe Acute Respiratory Infections (SARI) and Influenza Like Illnesses (ILI) in the Philippines.
With the emergence of the COVID-19 pandemic, the SNL-EREID Laboratory was instrumental in the identification of SARS-CoV-2 infected individuals through RT-PCR based assay.
- SARS-CoV-2 RT-PCR
- SARS-CoV-2 Rapid Antigen Test
- SARI RT-PCR
- COVID-19 Laboratory RT-PCR Hands-On Training
Cognizant of our clients’ safety and convenience in this time of pandemic, the Department has created the One Stop Swab and Drive Thru services wherein clients needing their COVID-19 tests done can be accommodated. The section is located at the old PCSO customer’s area.
- Nasopharyngeal/Oropharyngeal Swab Collection for SARS-CoV-2 Tests
- Blood collection (phlebotomy) for Chemistry, Hematology, and Immunology Tests
LABORATORY PATIENT SERVICES
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The Out-Patient Laboratory Services is the frontline service of the Pathology and Laboratory Medicine Department.
It is responsible for collection and receiving of specimen and releasing of laboratory results.
It is also in charge of patient preparation and specimen transportation for send-out to referral laboratories. It is also the laboratory service in charge of research collaboration with other departments and institutions.
The Out-Patient Laboratory Services is open Monday to Saturday from 7am to 5pm.
The LCP-General Anatomic Pathology Division deals with the diagnosis of organs, tissues and cells through gross and microscopic examination under the functional arm of surgical pathology, cytopathology and basic immunohistochemistry. Whereas, the National Reference Laboratory-Anatomic Pathology for Pulmonary Diseases is a program by the Department of Health (DOH) that designates the Lung Center of the Philippines (stated in the Department Personnel Order No. 2009-5148, issued on December 21, 2009) as reference laboratory, bounded by its mandates: to provide the country’s confirmatory diagnostic testing and innovative referral system in the field of Pulmonary Pathology by its trained personnel and advanced diagnostic equipment and services; to provide teaching and training of laboratory and non-laboratory partners; to engage in field research and research collaborations; and to cater external quality assurance program to stakeholders to include validation of diagnostic tests in anatomic pathology on Lung and Pleural specimens.
Now these two (2) integrated divisions function hand in hand in offering a wide range of timely, quality and breakthrough services to the institution.
Under the General Anatomic Pathology division are histopathology services; starting from tissue fixation, grossing, automated tissue processing and embedding, microsectioning, H & E, immunohistochemistry (IHC) staining and microscopic examination. We offer an extensive list of affordable immunohistochemistry panels including the recently introduced Reflex IHC testing which aims a faster turn-around time and a more directed immunohistochemistry testing for routine small biopsy and cytology specimens that warrant prompt therapeutic decisions and management upfront. Intraoperative Frozen Section processing is also available for quick intraoperative diagnosis to guide surgeons in surgical decision making.
Cytopathology services showcase the technical skills of in-house histotechnicians in preserving delicate cytology samples for futher confirmatory diagnostic testing. Aside from routine cytology processing of smears and cellblock, we also offer Rapid On-Site Evaluation (ROSE), a procedural technique to assess sample adequacy, specimen triaging and more importantly, to provide preliminary cytopathologic interpretation to onsite interventionists.
To benchmark with local and international competitors, we maintain our standards by performing internal quality control systems; update our laboratory operating documents and guidelines on par with global standards and recommendations. We regularly participate in the International Quality Assurance Programs conducted by the field experts in the United Kingdom and Australasia.
We have a team of pathologists trained in diverse areas in anatomic pathology and specialization in Lung Pathology who are actively engaged in multidisciplanary consultations and institutional referrals.
Procedures done include:
- Surgical pathology
- Intraoperative Frozen section consultation
- Rapid OnSite Evaluation (ROSE)
- Rapid Cytology
- Special Stains
- AFB stain
- Giemsa stain
- Grocott-Gomori methenamine silver stain
- Periodic Acid Schiff stain, with or without diastase
- Mucicarmine stain
- Reticulin stain
- Masson trichrome stain
- Elastin stain
- Basic Immunohistochemistry and Molecular Biomarker Stains
- ALK (D5F3)
- CD45/ LCA
- CK 5/6
- CK/ Cytokeratin
- Napsin A
- NKX 3.1
- Smooth Muscle Actin (SMA)
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The laboratory offers a promising area of hope for the amelioration of many diseases for which there has previously been no cure and minimal chance of prevention.
The Stem Cell Laboratory provides quality, autologous dendritic cell vaccines and other autologous adult stem cell-based therapies. For active immunotherapy, dendritic cells are used to trigger the immune response against diseases including cancer. For regenerative purposes, autologous adult stem cells are administered to mediate repair of affected tissues.
Services offered include:
- Immune Cell Therapy (Dendritic Cell Therapy)
- Circulating Tumor Cell Count
- Regenerative Therapy (MSC, EPC)
- 3 and 6 Gene Expression (Tumor Gene Expression Panel)
- EGFR Test
With continuing advancement in clinical laboratory technology, the Department of Health (DOH) has updated the standards for clinical laboratories to ensure the attainment of quality in laboratory services. DOH Department Order No. 393E s. 2000 was issued on November 14, 2000, designating the Lung Center of the Philippines as the National Reference Laboratory for Clinical Chemistry.
Mandated functions include the following:
- Maintain a Quality Assurance Program (QAP) for laboratory testing in coordination with the DOH-Bureau of Health Facilities and Services (BHFS),
- Train laboratory personnel,
- Evaluate test kits and reagents in coordination with the Philippine Food and Drug Administration and the Bureau of Health Devices and Technology,
- Provide laboratory referral services, confirmatory testing, surveillance and research
The National Reference Laboratory for Clinical Chemistry oversees the National External Quality Assurance Scheme (NEQAS) for Clinical Chemistry. It encourages all laboratories around the country that perform clinical chemistry examinations to participate in the program. The program helps ensure that clinical chemistry test results are accurate, reliable and comparable wherever they are produced in the country.
Pathology and Laboratory Department, Lung Center of the Philippines
Quezon Avenue, Quezon City, 1104 Philippines
Telephone Number: 8924-6101